The use of a synthetic cannabinoid in the management of treatment-resistant nightmares in posttraumatic stress disorder (PTSD).
نویسنده
چکیده
UNLABELLED This is the report of an open label clinical trial to evaluate the effects of nabilone, an endocannabinoid receptor agonist, on treatment-resistant nightmares in patients diagnosed with posttraumatic stress disorder (PTSD). METHODS Charts of 47 patients diagnosed with PTSD and having continuing nightmares in spite of conventional antidepressants and hypnotics were reviewed after adjunctive treatment with nabilone was initiated. These patients had been referred to a psychiatric specialist outpatient clinic between 2004 and 2006. The majority of patients (72%) receiving nabilone experienced either cessation of nightmares or a significant reduction in nightmare intensity. Subjective improvement in sleep time, the quality of sleep, and the reduction of daytime flashbacks and nightsweats were also noted by some patients. The results of this study indicate the potential benefits of nabilone, a synthetic cannabinoid, in patients with PTSD experiencing poor control of nightmares with standard pharmacotherapy. This is the first report of the use of nabilone (Cesamet; Valeant Canada, Ltd., Montreal, Canada) for the management of treatment-resistant nightmares in PTSD.
منابع مشابه
Use of a Synthetic Cannabinoid in a Correctional Population for Posttraumatic Stress Disorder–Related Insomnia and Nightmares, Chronic Pain, Harm Reduction, and Other Indications
Nabilone is a synthetic cannabinoid that has shown promise for the treatment of posttraumatic stress disorder (PTSD)-related insomnia and nightmares as well as efficacy in the management of chronic pain. It has also been proposed for harm reduction in cannabis dependence. Its effectiveness for management of concurrent disorders in seriously mentally ill correctional populations has not been eva...
متن کاملO2: Posttraumatic Stress Disorder and Substance Use Disorder: A Review of the U.S. VA/DOD Clinical Practice Guidelines and the Utility of Integrated Care
Post-traumatic stress disorder (PTSD) is a common mental health condition among military veterans, and research indicates that lifetime prevalence rates of PTSD among military veterans are higher than that of the general population (SAMHSA, 2007). The treatment of PTSD is often complicated by issues of comorbidity, such as substance use disorders, and treatment outcomes are poorer when comorbid...
متن کاملUse and effects of cannabinoids in military veterans with posttraumatic stress disorder.
PURPOSE Published evidence regarding the use of cannabis and cannabis derivatives by military veterans with posttraumatic stress disorder (PTSD) is reviewed. SUMMARY When inhaled or delivered orally or transdermally, cannabinoids (the psychoactive components of unrefined marijuana and various derivative products) activate endogenous cannabinoid receptors, modulating neurotransmitter release a...
متن کاملO3: Review of Evidence-Based and Experimental Treatment of Posttraumatic Stress Disorder
Post-traumatic stress disorder (PTSD) is a distressing condition, which is often treated with psychological and/or pharmacological therapies. The talk will give information about current treatment regimes in PTSD which haven proven evidence in reviews and meta-analysis. Furthermore, new and somewhat experimental treatments will be presented to provide insights into new treatment approaches.
متن کاملO8: The Impact of Physical Activity on Posttraumatic Stress Disorder
Posttraumatic stress disorder (PTSD) occurs following exposure to potentially traumatic experiences such as those regularly encountered by emergency service workers (police, ambulance and firemen/women) and servicemen/women. PTSD is associated with high rates of somatic comorbidities including metabolic syndrome contributing to an excess mortality rate due to preventable cardiovascular diseases...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- CNS neuroscience & therapeutics
دوره 15 1 شماره
صفحات -
تاریخ انتشار 2009